Identifying protein aggregation mechanisms and quantifying aggregation rates from combined monomer depletion and continuous scattering.

Barnett, Gregory V; Drenski, Michael; Razinkov, Vladimir; Reed, Wayne F; Roberts, Christopher J

Identifying protein aggregation mechanisms and quantifying aggregation rates from combined monomer depletion and continuous scattering.

Barnett, Gregory V; Drenski, Michael; Razinkov, Vladimir; Reed, Wayne F; Roberts, Christopher J.

Afiliação

Barnett GV; Department of Chemical & Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA.
Drenski M; Department of Physics, Tulane University, New Orleans, LA 70118, USA.
Razinkov V; Drug Product Development, Amgen, Thousand Oaks, CA 91320, USA.
Reed WF; Department of Physics, Tulane University, New Orleans, LA 70118, USA. Electronic address: wreed@tulane.edu.
Roberts CJ; Department of Chemical & Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA. Electronic address: cjr@udel.edu.

Anal Biochem ; 511: 80-91, 2016 10 15.

Article em En | MEDLINE | ID: mdl-27510552

Assuntos

Imunoglobulina G/química; Luz; Modelos Químicos; Agregados Proteicos; Espalhamento de Radiação; Animais; Camundongos; Estreptavidina/antagonistas & inibidores; Estreptavidina/química

Palavras-chave

Aggregation mechanisms; Aggregation rates; Laser scattering; Protein stability

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espalhamento de Radiação / Imunoglobulina G / Agregados Proteicos / Luz / Modelos Químicos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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