Enhancement of active MMP release and invasive activity of lymph node metastatic tongue cancer cells by elevated signaling via the TNF-&#945;-TNFR1-NF-&#954;B pathway and a possible involvement of angiopoietin-like 4 in lung metastasis.

Tanaka, Takuya; Imamura, Takahisa; Yoneda, Masakazu; Irie, Atsushi; Ogi, Hidenao; Nagata, Masashi; Yoshida, Ryoji; Fukuma, Daiki; Kawahara, Kenta; Shinohara, Masanori; Nakayama, Hideki

Enhancement of active MMP release and invasive activity of lymph node metastatic tongue cancer cells by elevated signaling via the TNF-α-TNFR1-NF-κB pathway and a possible involvement of angiopoietin-like 4 in lung metastasis.

Tanaka, Takuya; Imamura, Takahisa; Yoneda, Masakazu; Irie, Atsushi; Ogi, Hidenao; Nagata, Masashi; Yoshida, Ryoji; Fukuma, Daiki; Kawahara, Kenta; Shinohara, Masanori; Nakayama, Hideki.

Afiliação

Tanaka T; Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Imamura T; Department of Molecular Pathology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Yoneda M; Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Irie A; Department of Immunogenetics, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Ogi H; Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Nagata M; Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Yoshida R; Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Fukuma D; Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Kawahara K; Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Shinohara M; Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Nakayama H; Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.

Int J Oncol ; 49(4): 1377-84, 2016 Oct.

Article em En | MEDLINE | ID: mdl-27511626

Assuntos

Angiopoietinas/metabolismo; Carcinoma de Células Escamosas/metabolismo; Neoplasias Pulmonares/metabolismo; Metaloproteinases da Matriz Secretadas/metabolismo; Receptores Tipo I de Fatores de Necrose Tumoral/genética; Neoplasias da Língua/metabolismo; Fator de Necrose Tumoral alfa/genética; Proteína 1 Semelhante a Angiopoietina; Proteínas Semelhantes a Angiopoietina; Animais; Carcinoma de Células Escamosas/genética; Carcinoma de Células Escamosas/patologia; Linhagem Celular Tumoral; Regulação Neoplásica da Expressão Gênica; Humanos; Metástase Linfática; Metaloproteinase 2 da Matriz/metabolismo; Metaloproteinase 9 da Matriz/metabolismo; Camundongos; Camundongos Nus; NF-kappa B/metabolismo; Invasividade Neoplásica; Transplante de Neoplasias; Transdução de Sinais; Neoplasias da Língua/genética; Neoplasias da Língua/patologia; Fator de Necrose Tumoral alfa/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Língua / Carcinoma de Células Escamosas / Fator de Necrose Tumoral alfa / Angiopoietinas / Receptores Tipo I de Fatores de Necrose Tumoral / Metaloproteinases da Matriz Secretadas / Neoplasias Pulmonares Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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