Chemical profiling of cerebrospinal fluid by multiple reaction monitoring mass spectrometry.
Analyst
; 141(18): 5252-5, 2016 Sep 21.
Article
em En
| MEDLINE
| ID: mdl-27517482
ABSTRACT
We report an accelerated biomarker discovery workflow and results of sample screening by mass spectrometry based on multiple reaction monitoring (MRM). This methodology shows promising initial results for the currently unsolved challenge of Parkinson's disease (PD) laboratory diagnosis by biomarker screening. Small molecules present in cerebrospinal fluid (CSF) at low parts per million levels are monitored using specific transitions connecting ion pairs. A set of such transitions constitutes a multidimensional chemical profile used to distinguish and characterize different CSF samples using multivariate statistical methods.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Espectrometria de Massas
/
Biomarcadores
/
Líquido Cefalorraquidiano
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article