A local innate immune response against Trypanosoma cruzi in the human placenta: The epithelial turnover of the trophoblast.
Microb Pathog
; 99: 123-129, 2016 Oct.
Article
em En
| MEDLINE
| ID: mdl-27554274
ABSTRACT
Congenital Chagas disease, caused by Trypanosoma cruzi, is partially responsible for the progressive globalization of Chagas disease despite of its low transmission rate. The probability of congenital transmission depends on complex interactions between the parasite, the maternal and fetus/newborn immune responses and placental factors, being the latter the least studied one. During transplacental transmission, the parasite must cross the placental barrier where the trophoblast, a continuous renewing epithelium, is the first tissue to have contact with the parasite. Importantly, the epithelial turnover is considered part of the innate immune system since pathogens, prior to cell invasion, must attach to the surface of cells. The trophoblast turnover involves cellular processes such as proliferation, differentiation and apoptotic cell death, all of them are induced by the parasite. In the present review, we analyze the current evidence about the trophoblast epithelial turnover as a local placental innate immune response.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Complicações Infecciosas na Gravidez
/
Trofoblastos
/
Trypanosoma cruzi
/
Doença de Chagas
/
Imunidade Inata
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article