TLR2 controls random motility, while TLR7 regulates chemotaxis of microglial cells via distinct pathways.

Ifuku, Masataka; Buonfiglioli, Alice; Jordan, Philipp; Lehnardt, Seija; Kettenmann, Helmut

Ifuku, Masataka; Buonfiglioli, Alice; Jordan, Philipp; Lehnardt, Seija; Kettenmann, Helmut.

Afiliação

Ifuku M; Cellular Neuroscience, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Buonfiglioli A; Cellular Neuroscience, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany; Institute of Cell Biology and Neurobiology, Charité-Universitätsmedizin, Berlin, Germany.
Jordan P; Cellular Neuroscience, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Lehnardt S; Institute of Cell Biology and Neurobiology, Charité-Universitätsmedizin, Berlin, Germany; Department of Neurology, Charité-Universitätsmedizin, Berlin, Germany.
Kettenmann H; Cellular Neuroscience, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany. Electronic address: kettenmann@mdc-berlin.de.

Brain Behav Immun ; 58: 338-347, 2016 Nov.

Article em En | MEDLINE | ID: mdl-27554518

Assuntos

Movimento Celular; Quimiotaxia; Glicoproteínas de Membrana/metabolismo; Microglia/metabolismo; Receptor 2 Toll-Like/metabolismo; Receptor 7 Toll-Like/metabolismo; Animais; Feminino; Masculino; Camundongos Endogâmicos C57BL; Proteínas Proto-Oncogênicas c-akt/metabolismo; Receptores Purinérgicos P2Y12/metabolismo

Palavras-chave

Akt; Chemotaxis; Migration; PI3K; Rac; Toll-like receptor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Movimento Celular / Quimiotaxia / Microglia / Receptor 2 Toll-Like / Receptor 7 Toll-Like Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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