Anti-tumor immunity elicited by direct intratumoral administration of a recombinant adenovirus expressing either IL-28A/IFN-&#955;2 or IL-29/IFN-&#955;1.

Hasegawa, K; Tagawa, M; Takagi, K; Tsukamoto, H; Tomioka, Y; Suzuki, T; Nishioka, Y; Ohrui, T; Numasaki, M

Anti-tumor immunity elicited by direct intratumoral administration of a recombinant adenovirus expressing either IL-28A/IFN-λ2 or IL-29/IFN-λ1.

Hasegawa, K; Tagawa, M; Takagi, K; Tsukamoto, H; Tomioka, Y; Suzuki, T; Nishioka, Y; Ohrui, T; Numasaki, M.

Afiliação

Hasegawa K; Laboratory of Clinical Science and Biomedicine, Faculty of Pharmaceutical Sciences, Josai University, Sakado, Japan.
Tagawa M; Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan.
Takagi K; Departments of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Tsukamoto H; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Tomioka Y; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Suzuki T; Departments of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Nishioka Y; Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.
Ohrui T; Division of Geriatric Pharmacotherapy, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Numasaki M; Laboratory of Clinical Science and Biomedicine, Faculty of Pharmaceutical Sciences, Josai University, Sakado, Japan.

Cancer Gene Ther ; 23(8): 266-77, 2016 08.

Article em En | MEDLINE | ID: mdl-27561689

Assuntos

Adenoviridae/genética; Terapia Genética; Vetores Genéticos/genética; Imunomodulação/genética; Neoplasias/genética; Neoplasias/imunologia; Transgenes; Animais; Linhagem Celular Tumoral; Modelos Animais de Doenças; Expressão Gênica; Vetores Genéticos/administração & dosagem; Antígenos de Histocompatibilidade Classe I/imunologia; Humanos; Injeções Intralesionais; Interferon gama/biossíntese; Interferons/genética; Interferons/metabolismo; Interleucina-12/farmacologia; Interleucinas/genética; Interleucinas/metabolismo; Melanoma Experimental; Camundongos; Camundongos Knockout; Neoplasias/patologia; Neoplasias/terapia; Subpopulações de Linfócitos T/imunologia; Subpopulações de Linfócitos T/metabolismo; Transdução Genética; Carga Tumoral/efeitos dos fármacos; Carga Tumoral/genética; Carga Tumoral/imunologia; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia Genética / Adenoviridae / Transgenes / Imunomodulação / Vetores Genéticos / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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