Infliximab therapy restores adiponectin expression in perivascular adipose tissue and improves endothelial nitric oxide-mediated vasodilation in mice with type 1 diabetes.

Nacci, Carmela; Leo, Valentina; De Benedictis, Leonarda; Potenza, Maria A; Sgarra, Luca; De Salvia, Maria A; Quon, Michael J; Montagnani, Monica

Nacci, Carmela; Leo, Valentina; De Benedictis, Leonarda; Potenza, Maria A; Sgarra, Luca; De Salvia, Maria A; Quon, Michael J; Montagnani, Monica.

Afiliação

Nacci C; Department of Biomedical Sciences and Human Oncology, Pharmacology Section, Medical School, University of Bari "Aldo Moro", Bari, Italy.
Leo V; Department of Biomedical Sciences and Human Oncology, Pharmacology Section, Medical School, University of Bari "Aldo Moro", Bari, Italy.
De Benedictis L; Department of Biomedical Sciences and Human Oncology, Pharmacology Section, Medical School, University of Bari "Aldo Moro", Bari, Italy.
Potenza MA; Department of Biomedical Sciences and Human Oncology, Pharmacology Section, Medical School, University of Bari "Aldo Moro", Bari, Italy.
Sgarra L; Department of Biomedical Sciences and Human Oncology, Pharmacology Section, Medical School, University of Bari "Aldo Moro", Bari, Italy.
De Salvia MA; Department of Biomedical Sciences and Human Oncology, Pharmacology Section, Medical School, University of Bari "Aldo Moro", Bari, Italy.
Quon MJ; Department of Biomedical Sciences and Human Oncology, Pharmacology Section, Medical School, University of Bari "Aldo Moro", Bari, Italy.
Montagnani M; Department of Biomedical Sciences and Human Oncology, Pharmacology Section, Medical School, University of Bari "Aldo Moro", Bari, Italy. Electronic address: monica.montagnani@uniba.it.

Vascul Pharmacol ; 87: 83-91, 2016 12.

Article em En | MEDLINE | ID: mdl-27565410

Assuntos

Tecido Adiposo/efeitos dos fármacos; Diabetes Mellitus Experimental/tratamento farmacológico; Diabetes Mellitus Tipo 1/tratamento farmacológico; Infliximab/farmacologia; Adiponectina/genética; Adiponectina/metabolismo; Tecido Adiposo/metabolismo; Animais; Células Cultivadas; Diabetes Mellitus Experimental/fisiopatologia; Diabetes Mellitus Tipo 1/fisiopatologia; Células Endoteliais/efeitos dos fármacos; Células Endoteliais/metabolismo; Humanos; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Masculino; Artérias Mesentéricas/metabolismo; Camundongos; Camundongos Endogâmicos BALB C; Óxido Nítrico/metabolismo; Óxido Nítrico Sintase Tipo III/genética; Óxido Nítrico Sintase Tipo III/metabolismo; Receptores de Adiponectina/genética; Receptores de Adiponectina/metabolismo; Estreptozocina; Fator de Necrose Tumoral alfa/antagonistas & inibidores; Vasodilatação/efeitos dos fármacos

Palavras-chave

Adiponectin (Ad); Infliximab; Perivascular adipose tissue (PVAT); Type1 diabetes mellitus (T1DM)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 1 / Infliximab Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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