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Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans.
Yang, Suk-Kyun; Hong, Myunghee; Oh, Hyunjung; Low, Hui-Qi; Jung, Seulgi; Ahn, Seonjoo; Kim, Youngjin; Baek, Jiwon; Lee, Cue Hyunkyu; Kim, Eunji; Kim, Kyung Mo; Ye, Byong Duk; Kim, Kyung-Jo; Park, Sang Hyoung; Lee, Ho-Su; Lee, Inchul; Shin, Hyoung Doo; Han, Buhm; McGovern, Dermot P B; Liu, Jianjun; Song, Kyuyoung.
Afiliação
  • Yang SK; Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • Hong M; Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
  • Oh H; Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
  • Low HQ; Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
  • Jung S; Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
  • Ahn S; Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
  • Kim Y; Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
  • Baek J; Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
  • Lee CH; Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Korea; Asan Institute for Life Sciences, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
  • Kim E; Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Korea; Asan Institute for Life Sciences, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea; Department of Chemistry, Seoul National University, Seoul, Korea.
  • Kim KM; Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
  • Ye BD; Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • Kim KJ; Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • Park SH; Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • Lee HS; Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • Lee I; Department of Pathology, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
  • Shin HD; Department of Life Science, Sogang University, Seoul, Korea.
  • Han B; Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Korea; Asan Institute for Life Sciences, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
  • McGovern DP; The F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  • Liu J; Human Genetics Group, Genome Institute of Singapore, Singapore.
  • Song K; Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea. Electronic address: kysong@amc.seoul.kr.
Gastroenterology ; 151(6): 1096-1099.e4, 2016 Dec.
Article em En | MEDLINE | ID: mdl-27569725
ABSTRACT
Recent genome-wide association studies have identified more than 200 regions that affect susceptibility to inflammatory bowel disease (IBD). However, identified common variants account for only a fraction of IBD heritability and largely have been identified in populations of European ancestry. We performed a genome-wide association study of susceptibility loci in Korean individuals, comprising a total of 1505 IBD patients and 4041 controls. We identified 2 new susceptibility loci for IBD at genome-wide

significance:

rs3766920 near PYGO2-SHC1 at 1q21 and rs16953946 in CDYL2 at 16q23. In addition, we confirmed associations, in Koreans, with 28 established IBD loci (P < 2.16 × 10-4). Our findings support the complementary value of genetic studies in different populations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromossomos Humanos Par 1 / Cromossomos Humanos Par 16 / Colite Ulcerativa / Doença de Crohn / Predisposição Genética para Doença / Povo Asiático Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Humans País/Região como assunto: Asia Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromossomos Humanos Par 1 / Cromossomos Humanos Par 16 / Colite Ulcerativa / Doença de Crohn / Predisposição Genética para Doença / Povo Asiático Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Humans País/Região como assunto: Asia Idioma: En Ano de publicação: 2016 Tipo de documento: Article