Effect of ulinastatin on serum inflammatory factors in Asian patients with acute pancreatitis before and after treatment: a meta-analysisâ©.
Int J Clin Pharmacol Ther
; 54(11): 890-898, 2016 Nov.
Article
em En
| MEDLINE
| ID: mdl-27569736
ABSTRACT
OBJECTIVE:
We applied a meta-analysis to explore the effect of ulinastatin (UTI) on the serum levels of C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) in Asian patients with acute pancreatitis (AP).METHODS:
Various databases were searched based on stringent inclusion and exclusion criteria to extract relevant cohort studies. Comprehensive Meta-analysis 2.0 (Biostat Inc., Englewood, NJ, USA) was applied for statistical analyses.RESULTS:
A total of 113 relevant studies (67 in Chinese, 46 in English) were initially retrieved. Finally, 11 eligible studies were enrolled in our meta-analysis with 399 pancreatitis patients. Meta-analysis results showed that after being treated with UTI, the serum levels of CRP, IL-6, and TNF-α were evidently decreased (CRP SMD = -2.697, 95% CI = -4.399 ~ -0.994, p = 0.002; IL-6 SMD = -5.268, 95% CI = -9.850 ~ -0.687, p = 0.024; TNF-α SMD = -5.666, 95% CI = -11.083 ~ -0.249, p = 0.040).CONCLUSION:
UTI can effectively reduce the serum levels of CRP, IL-6, and TNF-α in Asian patients with AP, suggesting that UTI has anti-inflammatory effect on Asian patients with AP.â©.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pancreatite
/
Glicoproteínas
/
Mediadores da Inflamação
/
Inibidores de Hidroximetilglutaril-CoA Redutases
/
Anti-Inflamatórios
Tipo de estudo:
Observational_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article