Long noncoding RNA #32 contributes to antiviral responses by controlling interferon-stimulated gene expression.
Proc Natl Acad Sci U S A
; 113(37): 10388-93, 2016 09 13.
Article
em En
| MEDLINE
| ID: mdl-27582466
ABSTRACT
Despite the breadth of knowledge that exists regarding the function of long noncoding RNAs (lncRNAs) in biological phenomena, the role of lncRNAs in host antiviral responses is poorly understood. Here, we report that lncRNA#32 is associated with type I IFN signaling. The silencing of lncRNA#32 dramatically reduced the level of IFN-stimulated gene (ISG) expression, resulting in sensitivity to encephalomyocarditis virus (EMCV) infection. In contrast, the ectopic expression of lncRNA#32 significantly suppressed EMCV replication, suggesting that lncRNA#32 positively regulates the host antiviral response. We further demonstrated the suppressive function of lncRNA#32 in hepatitis B virus and hepatitis C virus infection. lncRNA#32 bound to activating transcription factor 2 (ATF2) and regulated ISG expression. Our results reveal a role for lncRNA#32 in host antiviral responses.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Interferon Tipo I
/
Fator 2 Ativador da Transcrição
/
Interações Hospedeiro-Patógeno
/
RNA Longo não Codificante
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article