Bevacizumab with preoperative chemotherapy versus preoperative chemotherapy alone for colorectal cancer liver metastases: a retrospective cohort study.
Medicine (Baltimore)
; 95(35): e4767, 2016 Aug.
Article
em En
| MEDLINE
| ID: mdl-27583930
ABSTRACT
This study aimed to assess the efficacy and safety of bevacizumab plus preoperative chemotherapy as first-line treatment for liver-only metastatic colorectal cancer in Chinese patients compared with those of preoperative chemotherapy alone.Patients with histologically confirmed liver-only metastatic colorectal cancer were sequentially reviewed, and received either preoperative chemotherapy plus bevacizumab (bevacizumab group, nâ=â32) or preoperative chemotherapy alone (chemotherapy group, nâ=â57). Progression-free survival, response rate, liver resection rate, conversion rate, and safety were analyzed.With median follow-up of 28.7 months, progression-free survival was 10.9 months (95% confidence interval 8.7-13.1 months) in bevacizumab group and 9.9 months (95% confidence interval 6.8-13.1 months) in chemotherapy group (Pâ=â0.472). Response rates were 59.4% in bevacizumab group and 38.6% in chemotherapy group (Pâ=â0.059). Overall liver resection (R0, R1, and R2) rate was 68.8% in bevacizumab group and 54.4% in chemotherapy group (Pâ=â0.185). Conversion rate was 51.9% in bevacizumab group and 40.4% in chemotherapy group (Pâ=â0.341). No postoperative complication was observed in all patients.Bevacizumab plus preoperative chemotherapy as first-line treatment for liver-only metastatic colorectal cancer tends to achieve better clinical benefit with controllable safety in Chinese patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
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Adenocarcinoma
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Protocolos de Quimioterapia Combinada Antineoplásica
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Inibidores da Angiogênese
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Bevacizumab
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Neoplasias Hepáticas
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article