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Asnovolins A-G, Spiromeroterpenoids Isolated from the Fungus Aspergillus novofumigatus, and Suppression of Fibronectin Expression by Asnovolin E.
Ishikawa, Kazuki; Sato, Fumiaki; Itabashi, Takeshi; Wachi, Hiroshi; Takeda, Hisashi; Wakana, Daigo; Yaguchi, Takashi; Kawai, Ken-Ichi; Hosoe, Tomoo.
Afiliação
  • Ishikawa K; Department of Organic Chemistry, Hoshi University , 2-4-41 Ebara, Shinagawa, Tokyo, Japan.
  • Sato F; Department of Organic Chemistry, Hoshi University , 2-4-41 Ebara, Shinagawa, Tokyo, Japan.
  • Itabashi T; Department of Organic Chemistry, Hoshi University , 2-4-41 Ebara, Shinagawa, Tokyo, Japan.
  • Wachi H; Department of Organic Chemistry, Hoshi University , 2-4-41 Ebara, Shinagawa, Tokyo, Japan.
  • Takeda H; Department of Organic Chemistry, Hoshi University , 2-4-41 Ebara, Shinagawa, Tokyo, Japan.
  • Wakana D; Department of Organic Chemistry, Hoshi University , 2-4-41 Ebara, Shinagawa, Tokyo, Japan.
  • Yaguchi T; Medical Mycology Research Center (MMRC), Chiba University , 1-8-1 Inohama, Chuo-ku, Chiba, Japan.
  • Kawai K; Department of Organic Chemistry, Hoshi University , 2-4-41 Ebara, Shinagawa, Tokyo, Japan.
  • Hosoe T; Department of Organic Chemistry, Hoshi University , 2-4-41 Ebara, Shinagawa, Tokyo, Japan.
J Nat Prod ; 79(9): 2167-74, 2016 09 23.
Article em En | MEDLINE | ID: mdl-27626956
ABSTRACT
Seven novel spiromeroterpenoids, asnovolins A-G (1-7), one of which was shown to suppress fibronectin expression, were isolated from Aspergillus novofumigatus CBS117520 along with a known compound, novofumigatonin (8). The structures of asnovolins A-G were elucidated using MS and 2D-NMR data. Asnovolin E (5) suppressed fibronectin expression by normal human neonatal dermal fibroblast cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Terpenos Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Terpenos Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article