The value of diffusion kurtosis magnetic resonance imaging for assessing treatment response of neoadjuvant chemoradiotherapy in locally advanced rectal cancer.
Eur Radiol
; 27(5): 1848-1857, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-27631106
ABSTRACT
OBJECTIVES:
To evaluate the feasibility and value of diffusion kurtosis (DK) imaging in assessing treatment response to neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC).METHODS:
Forty-one patients were included. All patients underwent pre- and post-CRT DCE-MRI on a 3.0-Tesla MRI scanner. Imaging indices (D app , K app and ADC values) were measured. Change value (∆X) and change ratio (r∆X) were calculated. Pathological tumour regression grade scores (Mandard) were the standard reference (good responders pTRG 1-2; poor responders pTRG 3-5). Diagnostic performance was compared using ROC analysis.RESULTS:
For the pre-CRT measurements, pre-D app-10th was significantly lower in the good responder group than that of the poor responder group (p = 0.036). For assessing treatment response to neoadjuvant CRT, pre-D app-10th resulted in AUCs of 0.753 (p = 0.036) with a sensitivity of 66.67 % and a specificity of 77.78 %. The r∆D app had a relatively high AUC (0.859) and high sensitivity (100 %) compared with other image indices.CONCLUSIONS:
DKI is feasible for selecting good responders for neoadjuvant CRT for LARC. KEY POINTS ⢠LARC responded well after neoadjuvant chemoradiotherapy with lower pre-D app-10th . ⢠LARC responded well with greater increases in mean ADC and D app . ⢠The change ratio of D app (r∆D app ) had a relatively better diagnostic performance.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Retais
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Carcinoma
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article