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Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude.
Kantae, Vasudev; Krekels, Elke H J; Ordas, Anita; González, Oskar; van Wijk, Rob C; Harms, Amy C; Racz, Peter I; van der Graaf, Piet H; Spaink, Herman P; Hankemeier, Thomas.
Afiliação
  • Kantae V; 1 Division of Analytical Biosciences, Systems Pharmacology Cluster, Leiden Academic Centre for Drug Research, Leiden University , Leiden, The Netherlands .
  • Krekels EH; 2 Division of Pharmacology, Systems Pharmacology Cluster, Leiden Academic Centre for Drug Research, Leiden University , Leiden, The Netherlands .
  • Ordas A; 3 IBL, Institute of Biology, Leiden University , Leiden, the Netherlands .
  • González O; 1 Division of Analytical Biosciences, Systems Pharmacology Cluster, Leiden Academic Centre for Drug Research, Leiden University , Leiden, The Netherlands .
  • van Wijk RC; 4 Science and Technology Faculty, Analytical Chemistry Department, University of the Basque Country/EHU , Bilbao, Spain .
  • Harms AC; 2 Division of Pharmacology, Systems Pharmacology Cluster, Leiden Academic Centre for Drug Research, Leiden University , Leiden, The Netherlands .
  • Racz PI; 1 Division of Analytical Biosciences, Systems Pharmacology Cluster, Leiden Academic Centre for Drug Research, Leiden University , Leiden, The Netherlands .
  • van der Graaf PH; 5 ZF-screens B.V. , Leiden, The Netherlands .
  • Spaink HP; 2 Division of Pharmacology, Systems Pharmacology Cluster, Leiden Academic Centre for Drug Research, Leiden University , Leiden, The Netherlands .
  • Hankemeier T; 3 IBL, Institute of Biology, Leiden University , Leiden, the Netherlands .
Zebrafish ; 13(6): 504-510, 2016 12.
Article em En | MEDLINE | ID: mdl-27632065
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Analgésicos não Narcóticos / Avaliação Pré-Clínica de Medicamentos / Acetaminofen / Modelos Teóricos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Analgésicos não Narcóticos / Avaliação Pré-Clínica de Medicamentos / Acetaminofen / Modelos Teóricos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article