Association between shortened telomere length and rheumatoid arthritis : A meta-analysis.
Z Rheumatol
; 77(2): 160-167, 2018 Mar.
Article
em En
| MEDLINE
| ID: mdl-27644953
ABSTRACT
OBJECTIVE:
This study aimed to evaluate the relationship between telomere length and rheumatoid arthritis (RA).METHODS:
We performed a meta-analysis of studies comparing the telomere length in RA patients and healthy controls, and conducted subgroup analysis based on ethnicity, age-matched status, study quality, sample type, assay method, subject number, and shared epitope (SE) status.RESULTS:
Nine studies from seven articles, with 388 RA patients and 362 controls, were included. Meta-analysis showed that the telomere length was significantly shorter in all individuals of the RA group than in those of the control group (SMD = -0.833, 95 % CI = -1.332 to -0.334, p = 0.001). Stratification by ethnicity showed significantly shortened telomere lengths in both mixed and age-matched Caucasian populations with RA (SMD = -1.415, 95 % CI = -1.709 to -1.120, p < 1.0 × 10-8; SMD = -0.658, 95 % CI = -1.187 to -0.0.128, p = 0.015). The telomere length was significantly shorter in the RA group than in the age-matched control group; however, this was not the case in the RA group that was not age-matched (SMD = -1.070, 95 % CI = -1.489 to -0.650, p = 5.7 × 10-7; SMD = 0.155, 95 % CI = -0.119 to 0.429, p = 0.267). Stratification by SE status revealed a significantly shortened telomere length in the SE-positive group, but not in the SE-negative group (SMD = -1.033, 95 % CI = -1.398 to -0.768, p < 1.0 × 10-8; SMD = -0.967, 95 % CI = -2.382 to 0.449, p = 0.181). In addition, the telomere length was significantly shorter in the SE-positive RA group than in the SE-negative RA group (SMD = -0.415, 95 % CI = -0.699 to -0.131, p = 0.004).CONCLUSIONS:
Our meta-analysis demonstrated that the telomere length was significantly shorter in patients with RA, and was significantly more so in the SE-positive group than in the SE-negative group.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Telômero
/
Encurtamento do Telômero
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article