[Significance of SATB2 in the pathologic diagnosis of osteosarcoma].
Zhonghua Bing Li Xue Za Zhi
; 45(9): 631-5, 2016 Sep 08.
Article
em Zh
| MEDLINE
| ID: mdl-27646893
ABSTRACT
OBJECTIVE:
To investigate the role of SATB2 in the pathological diagnosis and differential diagnosis of osteosarcoma.METHODS:
Immunostaining of SATB2 was performed in 47 cases of osteosarcomas, 5 osteoblastomas, 4 fibrous dysplasias, 5 myositis ossificans, 10 chondroblastomas, 8 chondrosarcomas, 5 Ewing sarcomas, 5 undifferentiated pleomorphic sarcomas, 6 fibrosarcomas and 2 leiomyosarcomas.RESULTS:
All osteoblastomas (5/5) and myositis ossificans (5/5), 83.0%(39/47) of osteosarcomas and 2/10 of chondroblastomas showed nuclear immunoreactivity for SATB2. SATB2 staining was negative in all cases of fibrous dysplasia, chondrosarcomas, Ewing sarcomas and all bone primary spindle cell sarcomas(undifferentiated pleomorphic sarcoma, fibrosarcoma and leiomyosarcoma).CONCLUSION:
SATB2 is a reliable osteoblastic marker for differential diagnosis of osteosarcoma and non-osteoid sarcoma, although with a limited role in separating osteosarcoma from non-malignant osteoblastic lesions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Neoplasias Ósseas
/
Biomarcadores Tumorais
/
Osteossarcoma
/
Proteínas de Ligação à Região de Interação com a Matriz
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2016
Tipo de documento:
Article