Angiotensin II receptor blocker combined with eplerenone or hydrochlorothiazide for hypertensive patients with diabetes mellitus.
Clin Exp Hypertens
; 38(7): 565-570, 2016.
Article
em En
| MEDLINE
| ID: mdl-27651039
ABSTRACT
Experimental models recently suggested an interaction between aldosterone and adipose tissue, but clinical investigation has been limited. We studied the effects of eplerenone compared to hydrochlorothiazide (HCTZ) on blood pressure (BP), glucose, and lipid levels in 50 patients with essential hypertension (EHT) and type 2 diabetes mellitus whose BP failed to reach target levels with 8 mg of candesartan alone. BP improved similarly in both groups over the 12-month study period, but BMI, waist circumference, and LDL-cholesterol were decreased in the eplerenone group, while glycohemoglobin was elevated in the HCTZ group.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espironolactona
/
Tetrazóis
/
Benzimidazóis
/
Pressão Sanguínea
/
Diabetes Mellitus Tipo 2
/
Hidroclorotiazida
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article