The EP1/EP3 receptor agonist 17-pt-PGE<sub>2</sub> acts as an EP4 receptor agonist on endothelial barrier function and in a model of LPS-induced pulmonary inflammation.

Theiler, Anna; Konya, Viktoria; Pasterk, Lisa; Maric, Jovana; Bärnthaler, Thomas; Lanz, Ilse; Platzer, Wolfgang; Schuligoi, Rufina; Heinemann, Akos

The EP1/EP3 receptor agonist 17-pt-PGE₂ acts as an EP4 receptor agonist on endothelial barrier function and in a model of LPS-induced pulmonary inflammation.

Theiler, Anna; Konya, Viktoria; Pasterk, Lisa; Maric, Jovana; Bärnthaler, Thomas; Lanz, Ilse; Platzer, Wolfgang; Schuligoi, Rufina; Heinemann, Akos.

Afiliação

Theiler A; Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4, 8010 Graz, Austria. Electronic address: anna.theiler@medunigraz.at.
Konya V; Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4, 8010 Graz, Austria. Electronic address: viktoria.konya@medunigraz.at.
Pasterk L; Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4, 8010 Graz, Austria. Electronic address: lisa.pasterk@medunigraz.at.
Maric J; Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4, 8010 Graz, Austria. Electronic address: jovana.maric@medunigraz.at.
Bärnthaler T; Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4, 8010 Graz, Austria. Electronic address: thomas.baernthaler@medunigraz.at.
Lanz I; Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4, 8010 Graz, Austria. Electronic address: ilse.lanz@medunigraz.at.
Platzer W; Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4, 8010 Graz, Austria. Electronic address: wolfgang.platzer@medunigraz.at.
Schuligoi R; Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4, 8010 Graz, Austria. Electronic address: rufina.schuligoi@medunigraz.at.
Heinemann A; Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4, 8010 Graz, Austria. Electronic address: akos.heinemann@medunigraz.at.

Vascul Pharmacol ; 87: 180-189, 2016 12.

Article em En | MEDLINE | ID: mdl-27664754

Assuntos

Dinoprostona/análogos & derivados; Inflamação/tratamento farmacológico; Pneumonia/tratamento farmacológico; Receptores de Prostaglandina E Subtipo EP4/agonistas; Animais; Plaquetas/efeitos dos fármacos; Plaquetas/metabolismo; Dinoprostona/farmacologia; Modelos Animais de Doenças; Células Endoteliais/efeitos dos fármacos; Células Endoteliais/metabolismo; Técnicas de Silenciamento de Genes; Humanos; Inflamação/patologia; Lipopolissacarídeos/toxicidade; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Infiltração de Neutrófilos/efeitos dos fármacos; Pneumonia/patologia; RNA Interferente Pequeno/administração & dosagem; Receptores de Prostaglandina E Subtipo EP1/agonistas; Receptores de Prostaglandina E Subtipo EP3/agonistas; Receptores de Prostaglandina E Subtipo EP4/genética

Palavras-chave

17-Phenyl-trinor-prostaglandin E(2); EP receptors; Endothelial barrier function; Platelet aggregation; Pulmonary inflammation; Vascular hyperpermeability

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia / Dinoprostona / Receptores de Prostaglandina E Subtipo EP4 / Inflamação Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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