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The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining.
Lee, Younghyun; Li, Huizi Keiko; Masaoka, Aya; Sunada, Shigeaki; Hirakawa, Hirokazu; Fujimori, Akira; Nickoloff, Jac A; Okayasu, Ryuichi.
Afiliação
  • Lee Y; Dept. of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, Chiba, Japan.
  • Li HK; Dept. of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, Chiba, Japan; Graduate School of Medical and Pharmaceutical Sciences, Chiba University, Japan.
  • Masaoka A; Dept. of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, Chiba, Japan.
  • Sunada S; Dept. of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, Chiba, Japan; Department of Nuclear Engineering and Management, School of Engineering, The University of Tokyo, Japan.
  • Hirakawa H; Dept. of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, Chiba, Japan.
  • Fujimori A; Dept. of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, Chiba, Japan.
  • Nickoloff JA; Department of Environmental and Radiological Health Sciences, Colorado State University, USA.
  • Okayasu R; Dept. of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, Chiba, Japan. Electronic address: okayasu.ryuichi@qst.go.jp.
Radiother Oncol ; 121(1): 162-168, 2016 10.
Article em En | MEDLINE | ID: mdl-27666928
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Purinas / Radiossensibilizantes / Proteínas de Choque Térmico HSP90 / Benzodioxóis / Neoplasias Pulmonares Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Purinas / Radiossensibilizantes / Proteínas de Choque Térmico HSP90 / Benzodioxóis / Neoplasias Pulmonares Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article