Early effects of fluoro-edenite: correlation between IL-18 serum levels and pleural and parenchymal abnormalities.
Future Oncol
; 12(23s): 59-62, 2016 Dec.
Article
em En
| MEDLINE
| ID: mdl-27669761
ABSTRACT
Fluoro-edenite (FE) is a natural mineral asbestos-like fibrous species first isolated in Biancavilla, Sicily. In order to clarify potential involvement of IL-18 in the pathogenesis of FE-induced chest abnormalities, we analyzed IL-18 serum levels in FE-exposed workers (FEEW) and correlated them with pleural and parenchymal abnormalities. A total of 21 FEEWs, residing in Biancavilla for >30 years, with a working seniority of 17 ± 6.1 years were examined. High-resolution computed tomography scans revealed low grade of fibrosis in 8 (38%) FEEWs, and pleural plaques (PPs) in 13 (62%) FEEWs. The mean IL-18 level was 203.13 ± 90.43 pg/ml. Pearson correlation showed a significant association (p < 0.0001) between IL-18 and PPs and parenchymal abnormality scores. Data suggest a potential role of IL-18 in the pathogenesis of these diseases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Pleurais
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Exposição Ocupacional
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Doenças Pulmonares Intersticiais
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Amiantos Anfibólicos
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Interleucina-18
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article