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Reduced tract integrity of the model for social communication is a neural substrate of social communication deficits in autism spectrum disorder.
Lo, Yu-Chun; Chen, Yu-Jen; Hsu, Yung-Chin; Tseng, Wen-Yih Isaac; Gau, Susan Shur-Fen.
Afiliação
  • Lo YC; Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan.
  • Chen YJ; The Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
  • Hsu YC; Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan.
  • Tseng WI; Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan.
  • Gau SS; Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan.
J Child Psychol Psychiatry ; 58(5): 576-585, 2017 May.
Article em En | MEDLINE | ID: mdl-27677901
BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with social communication deficits as one of the core symptoms. Recently, a five-level model for the social communication has been proposed in which white matter tracts corresponding to each level of the model are identified. Given that the model for social communication subserves social language functions, we hypothesized that the tract integrity of the model for social communication may be reduced in ASD, and the reduction may be related to social communication deficits. METHODS: Sixty-two right-handed boys with ASD and 55 typically developing (TD) boys received clinical evaluations, intelligence tests, the Social Communication Questionnaire (SCQ), and MRI scans. Generalized fractional anisotropy (GFA) was measured by diffusion spectrum imaging to indicate the microstructural integrity of the tracts for each level of the social communication model. Group difference in the tract integrity and its relationship with the SCQ subscales of social communication and social interaction were investigated. RESULTS: We found that the GFA values of the superior longitudinal fasciculus III (SLF III, level 1) and the frontal aslant tracts (FAT, level 2) were decreased in ASD compared to TD. Moreover, the GFA values of the SLF III and the FAT were associated with the social interaction subscale in ASD. CONCLUSIONS: The tract integrity of the model for social communication is reduced in ASD, and the reduction is associated with impaired social interaction. Our results support that reduced tract integrity of the model for social communication might be a neural substrate of social communication deficits in ASD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comunicação / Substância Branca / Transtorno do Espectro Autista / Relações Interpessoais Limite: Adolescent / Adult / Child / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comunicação / Substância Branca / Transtorno do Espectro Autista / Relações Interpessoais Limite: Adolescent / Adult / Child / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article