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Filamentation protects Candida albicans from amphotericin B-induced programmed cell death via a mechanism involving the yeast metacaspase, MCA1.
Laprade, David J; Brown, Melissa S; McCarthy, Morgan L; Ritch, James J; Austriaco, Nicanor.
Afiliação
  • Laprade DJ; Department of Biology, Providence College, 1 Cunningham Square, Providence, Rhode Island 02918, U.S.A.
  • Brown MS; Department of Biology, Providence College, 1 Cunningham Square, Providence, Rhode Island 02918, U.S.A.
  • McCarthy ML; Department of Biology, Providence College, 1 Cunningham Square, Providence, Rhode Island 02918, U.S.A.
  • Ritch JJ; Department of Biology, Providence College, 1 Cunningham Square, Providence, Rhode Island 02918, U.S.A.
  • Austriaco N; Department of Biology, Providence College, 1 Cunningham Square, Providence, Rhode Island 02918, U.S.A.
Microb Cell ; 3(7): 285-292, 2016 Jul.
Article em En | MEDLINE | ID: mdl-27683660
The budding yeast Candida albicans is one of the most significant fungal pathogens worldwide. It proliferates in two distinct cell types: blastopores and filaments. Only cells that are able to transform from one cell type into the other are virulent in mouse disease models. Programmed cell death is a controlled form of cell suicide that occurs when C. albicans cells are exposed to fungicidal drugs like amphotericin B and caspofungin, and to other stressful conditions. We now provide evidence that suggests that programmed cell death is cell-type specific in yeast: Filamentous C. albicans cells are more resistant to amphotericin B- and caspofungin-induced programmed cell death than their blastospore counterparts. Finally, our genetic data suggests that this phenomenon is mediated by a protective mechanism involving the yeast metacaspase, MCA1.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article