[The clinical characteristics of 128 childhood- and adolescent-onset hypoparathyroidism in Peking Union Medical College Hospital: a retrospective analysis].
Zhonghua Nei Ke Za Zhi
; 55(10): 769-773, 2016 Oct 01.
Article
em Zh
| MEDLINE
| ID: mdl-27686437
ABSTRACT
Objective:
To study the clinical characteristics of childhood- and adolescent- onset hypoparathyroidism.Methods:
The clinical data of 128 hypoparathyroidism patients with onset before the age of 18 years were collected and analyzed retrospectively.Results:
The predominant features of the hypoparathyroidism were carpopedal spasm (89.3%, 108/121) and seizures (66.1%, 84/127). Intracranial calcification was identified in 89.4%(101/113) of the patients. Duration is an independent predictive factor (OR=1.483, P=0.011) for intracranial calcification. All the patients were treated with calcium and vitamin D or its metabolites. Hypercalciuria was associated with serum calcium (P=0.016).Conclusions:
Carpopedal spasm and seizures were the main manifestations of childhood- and adolescent- onset hypoparathyroidism. Calcium and vitamin D or its metabolites are effective. Monitoring the concentration of serum and urinary calcium is of highly importance for the prevention of hypercalciuria.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Convulsões
/
Vitamina D
/
Cálcio
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Hipocalcemia
/
Hipoparatireoidismo
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
Zh
Ano de publicação:
2016
Tipo de documento:
Article