Mechanosensor polycystin-1 potentiates differentiation of human osteoblastic cells by upregulating Runx2 expression via induction of JAK2/STAT3 signaling axis.

Dalagiorgou, Georgia; Piperi, Christina; Adamopoulos, Christos; Georgopoulou, Urania; Gargalionis, Antonios N; Spyropoulou, Anastasia; Zoi, Ilianna; Nokhbehsaim, Marjan; Damanaki, Anna; Deschner, James; Basdra, Efthimia K; Papavassiliou, Athanasios G

Dalagiorgou, Georgia; Piperi, Christina; Adamopoulos, Christos; Georgopoulou, Urania; Gargalionis, Antonios N; Spyropoulou, Anastasia; Zoi, Ilianna; Nokhbehsaim, Marjan; Damanaki, Anna; Deschner, James; Basdra, Efthimia K; Papavassiliou, Athanasios G.

Afiliação

Dalagiorgou G; Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75, M. Asias Street, 11527, Athens, Greece.
Piperi C; Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75, M. Asias Street, 11527, Athens, Greece.
Adamopoulos C; Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75, M. Asias Street, 11527, Athens, Greece.
Georgopoulou U; Molecular Virology Laboratory, Hellenic Pasteur Institute, 11521, Athens, Greece.
Gargalionis AN; Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75, M. Asias Street, 11527, Athens, Greece.
Spyropoulou A; Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75, M. Asias Street, 11527, Athens, Greece.
Zoi I; Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75, M. Asias Street, 11527, Athens, Greece.
Nokhbehsaim M; Section of Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111, Bonn, Germany.
Damanaki A; Section of Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111, Bonn, Germany.
Deschner J; Section of Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111, Bonn, Germany.
Basdra EK; Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75, M. Asias Street, 11527, Athens, Greece. ebasdra@med.uoa.gr.
Papavassiliou AG; Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75, M. Asias Street, 11527, Athens, Greece. papavas@med.uoa.gr.

Cell Mol Life Sci ; 74(5): 921-936, 2017 03.

Article em En | MEDLINE | ID: mdl-27699453

Assuntos

Diferenciação Celular; Subunidade alfa 1 de Fator de Ligação ao Core/genética; Janus Quinase 2/metabolismo; Mecanotransdução Celular; Osteoblastos/citologia; Fator de Transcrição STAT3/metabolismo; Canais de Cátion TRPP/metabolismo; Regulação para Cima/genética; Sequência de Bases; Linhagem Celular; Núcleo Celular/metabolismo; Subunidade alfa 1 de Fator de Ligação ao Core/metabolismo; DNA/metabolismo; Humanos; Modelos Biológicos; Osteoblastos/metabolismo; Fosforilação; Regiões Promotoras Genéticas; Ligação Proteica; Transporte Proteico; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Transdução de Sinais; Canais de Cátion TRPP/química

Palavras-chave

Gene regulation; JAK/STAT pathway; Mechanosensor; Mechanotransduction; Osteoblastic differentiation; Polycystin-1; Runx2

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoblastos / Diferenciação Celular / Regulação para Cima / Mecanotransdução Celular / Fator de Transcrição STAT3 / Canais de Cátion TRPP / Subunidade alfa 1 de Fator de Ligação ao Core / Janus Quinase 2 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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