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Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition.
Murai, Junko; Feng, Ying; Yu, Guoying K; Ru, Yuanbin; Tang, Sai-Wen; Shen, Yuqiao; Pommier, Yves.
Afiliação
  • Murai J; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Feng Y; BioMarin Pharmaceutical Inc., Novato, CA, USA.
  • Yu GK; BioMarin Pharmaceutical Inc., Novato, CA, USA.
  • Ru Y; BioMarin Pharmaceutical Inc., Novato, CA, USA.
  • Tang SW; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Shen Y; Current affiliation: Division of Blood and Marrow Transplantation, Department of Medicine, Stranford University School of Medicine, Stanford, CA, USA.
  • Pommier Y; BioMarin Pharmaceutical Inc., Novato, CA, USA.
Oncotarget ; 7(47): 76534-76550, 2016 Nov 22.
Article em En | MEDLINE | ID: mdl-27708213
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Resistencia a Medicamentos Antineoplásicos / Inativação Gênica / Proteínas Mutadas de Ataxia Telangiectasia / Inibidores de Poli(ADP-Ribose) Polimerases / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Resistencia a Medicamentos Antineoplásicos / Inativação Gênica / Proteínas Mutadas de Ataxia Telangiectasia / Inibidores de Poli(ADP-Ribose) Polimerases / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article