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Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition.
Huisman, Matthew; White, Jessica K; Lewalski, Veronica G; Podgorski, Izabela; Turro, Claudia; Kodanko, Jeremy J.
Afiliação
  • Huisman M; Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. jkodanko@chem.wayne.edu.
  • White JK; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA. turro1@osu.edu.
  • Lewalski VG; Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. jkodanko@chem.wayne.edu.
  • Podgorski I; Department of Pharmacology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA and Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.
  • Turro C; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA. turro1@osu.edu.
  • Kodanko JJ; Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. jkodanko@chem.wayne.edu and Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.
Chem Commun (Camb) ; 52(85): 12590-12593, 2016 Oct 18.
Article em En | MEDLINE | ID: mdl-27711349
ABSTRACT
Photochemical control over irreversible inhibition was shown using Ru(ii)-caged inhibitors of cathepsin L. Levels of control were dependent on where the Ru(ii) complex was attached to the organic inhibitor, reaching >10 1 with optimal placement. A new strategy for photoreleasing Ru(ii) fragments from inhibitor-enzyme conjugates is also reported.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article