Palladium meets copper: one-pot tandem synthesis of pyrido fused heterocycles via Sonogashira conjoined electrophilic cyclization.
Org Biomol Chem
; 14(38): 9063-9071, 2016 Sep 26.
Article
em En
| MEDLINE
| ID: mdl-27714281
ABSTRACT
An efficient step-economical tandem approach for the direct synthesis of pyrido fused indole, quinoline, benzofuran and benzothiophene derivatives using a bimetallic Pd/Cu catalytic system has been described. The three component reaction of o-halo aldehydes, alkynes and tert-butylamine leads to the synthesis of biologically active polyheterocycles. The present strategy involves the dual role of tert-butylamine and copper(i) in Sonogashira coupling followed by electrophilic cyclization through imine formation. The chemistry has been validated by X-ray crystallographic studies.
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01-internacional
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MEDLINE
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En
Ano de publicação:
2016
Tipo de documento:
Article