Bioavailability of nifedipine from different oral dosage forms in healthy volunteers.
Pharmazie
; 44(5): 336-8, 1989 May.
Article
em En
| MEDLINE
| ID: mdl-2772014
ABSTRACT
The absolute and relative bioavailability of nifedipine (1) from different formulations administered as single oral doses in healthy volunteers was determined. Serum concentrations of 1 were measured by GC. The absolute bioavailability of 1 was 53% because of presystemic metabolism. The bioavailability of Adalat (Bayer) tablets, Nifedipina (Terapia) and Corinfar (VEB Arzneimittelwerk Dresden) sugar-coated tablets was 93%, 92% and 86% (respectively) as compared with Adalat capsules. The AUC were not significantly different. The Cmax and tmax values were different, indicating that the absorption of 1 showed differences in first-order rate constants of dissolution in the above mentioned order. Despite the differences among the formulations studied, each preparation may have its merits. In a multiple dose regimen of 20 mg 1 (Nifedipina, Terapia) t.i.d., minimal therapeutic drug levels were achieved and maintained during steady state, from the 1st d of treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nifedipino
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article