Serine is a new target residue for endogenous ADP-ribosylation on histones.
Nat Chem Biol
; 12(12): 998-1000, 2016 Dec.
Article
em En
| MEDLINE
| ID: mdl-27723750
ABSTRACT
ADP-ribosylation (ADPr) is a biologically and clinically important post-translational modification, but little is known about the amino acids it targets on cellular proteins. Here we present a proteomic approach for direct in vivo identification and quantification of ADPr sites on histones. We have identified 12 unique ADPr sites in human osteosarcoma cells and report serine ADPr as a new type of histone mark that responds to DNA damage.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Serina
/
Histonas
/
Difosfato de Adenosina
/
Processamento de Proteína Pós-Traducional
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article