Osteopontin directly modulates cytokine expression of primary microglia and increases their survival.
J Neuroimmunol
; 299: 130-138, 2016 10 15.
Article
em En
| MEDLINE
| ID: mdl-27725111
ABSTRACT
Osteopontin (OPN) is constitutively expressed in the brain and upregulated during neuroinflammation, e.g., focal cerebral ischemia. In OPN-deficient mice, microglia are deregulated after ischemia, but specific OPN-effects on microglia remain elusive. Primary microglia were cultured in the presence or absence of OPN. The survival of microglia under stress conditions was dose-dependently increased by OPN. Lipopolysaccharides (LPS)-induced release of nitric oxide (NO), TNF-α, and IL-6, as well as expression of inducible Nitric Oxide Synthase (iNOS), were attenuated by OPN. Data suggest that OPN modulates microglia function by shifting their inflammatory profile towards a neutral anti-inflammatory phenotype.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citocinas
/
Microglia
/
Osteopontina
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article