Perilymph pharmacokinetics of locally-applied gentamicin in the guinea pig.

Salt, A N; Hartsock, J J; Gill, R M; King, E; Kraus, F B; Plontke, S K

Salt, A N; Hartsock, J J; Gill, R M; King, E; Kraus, F B; Plontke, S K.

Afiliação

Salt AN; Department of Otolaryngology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis MO, USA. Electronic address: salta@ent.wustl.edu.
Hartsock JJ; Department of Otolaryngology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis MO, USA.
Gill RM; Department of Otolaryngology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis MO, USA.
King E; Bionics Institute of Australia, Melbourne VIC, Australia.
Kraus FB; Zentrallabor, Department of Laboratory Medicine, University Hospital Halle, Ernst Grube Str. 40, 06120 Halle (Saale), Germany.
Plontke SK; Department of Otorhinolaryngology, Head and Neck Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Hear Res ; 342: 101-111, 2016 12.

Article em En | MEDLINE | ID: mdl-27725177

Assuntos

Gentamicinas/administração & dosagem; Gentamicinas/metabolismo; Gentamicinas/farmacocinética; Perilinfa/metabolismo; Animais; Cobaias; Humanos; Doença de Meniere/tratamento farmacológico; Modelos Biológicos; Janela da Cóclea/metabolismo; Rampa do Tímpano/metabolismo; Canais Semicirculares/metabolismo; Vestíbulo do Labirinto/metabolismo

Palavras-chave

Cochleotoxicity; Distribution; Drug delivery; Elimination; Intratympanic; Permeability; Round window; Stapes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Perilinfa / Gentamicinas Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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