Shape matters: the complex relationship between aggregation and toxicity in protein-misfolding diseases.

Ries, Heidrun Maja; Nussbaum-Krammer, Carmen

Ries, Heidrun Maja; Nussbaum-Krammer, Carmen.

Afiliação

Ries HM; Center for Molecular Biology of Heidelberg University (ZMBH) and German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Heidelberg 69120, Germany.
Nussbaum-Krammer C; Center for Molecular Biology of Heidelberg University (ZMBH) and German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Heidelberg 69120, Germany c.nussbaum@zmbh.uni-heidelberg.de.

Essays Biochem ; 60(2): 181-190, 2016 10 15.

Article em En | MEDLINE | ID: mdl-27744334

Assuntos

Agregados Proteicos; Deficiências na Proteostase/metabolismo; Amiloide/metabolismo; Humanos; Modelos Biológicos; Chaperonas Moleculares/metabolismo; Príons/metabolismo

Palavras-chave

amyloid fibrils; neurodegenerative diseases; oligomers; prion strains; prion-like propagation; protein aggregation; protein conformation; protein disaggregation; protein homoeostasis; protein-misfolding disorders; proteostasis; proteotoxicity

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Deficiências na Proteostase / Agregados Proteicos Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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