Adaptive working memory strategy training in early Alzheimer's disease: randomised controlled trial.
Br J Psychiatry
; 210(1): 61-66, 2017 01.
Article
em En
| MEDLINE
| ID: mdl-27758836
ABSTRACT
BACKGROUND:
Interventions that improve cognitive function in Alzheimer's disease are urgently required.AIMS:
To assess whether a novel cognitive training paradigm based on 'chunking' improves working memory and general cognitive function, and is associated with reorganisation of functional activity in prefrontal and parietal cortices (trial registration ISRCTN43007027).METHOD:
Thirty patients with mild Alzheimer's disease were randomly allocated to receive 18 sessions of 30 min of either adaptive chunking training or an active control intervention over approximately 8 weeks. Pre- and post-intervention functional magnetic resonance imaging (fMRI) scans were also conducted.RESULTS:
Adaptive chunking training led to significant improvements in verbal working memory and untrained clinical measures of general cognitive function. Further, fMRI revealed a bilateral reduction in task-related lateral prefrontal and parietal cortex activation in the training group compared with controls.CONCLUSIONS:
Chunking-based cognitive training is a simple and potentially scalable intervention to improve cognitive function in early Alzheimer's disease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lobo Parietal
/
Transferência de Experiência
/
Córtex Pré-Frontal
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Função Executiva
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Doença de Alzheimer
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Remediação Cognitiva
/
Memória de Curto Prazo
Tipo de estudo:
Clinical_trials
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article