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Targeted Co-delivery of PTX and TR3 siRNA by PTP Peptide Modified Dendrimer for the Treatment of Pancreatic Cancer.
Li, Yang; Wang, Hebin; Wang, Kai; Hu, Qinglian; Yao, Qi; Shen, Youqing; Yu, Guocan; Tang, Guping.
Afiliação
  • Li Y; Institute of Chemical Biology and Pharmaceutical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou, 310028, China.
  • Wang H; Institute of Chemical Biology and Pharmaceutical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou, 310028, China.
  • Wang K; College of Life Sciences, Tarim University, Alar, 843300, China.
  • Hu Q; Institute of Chemical Biology and Pharmaceutical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou, 310028, China.
  • Yao Q; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310032, China.
  • Shen Y; Institute of Chemical Biology and Pharmaceutical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou, 310028, China.
  • Yu G; Center for Bionanoengineering and State Key Laboratory for Chemical Engineering, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
  • Tang G; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.
Small ; 13(2)2017 Jan.
Article em En | MEDLINE | ID: mdl-27762495
A new type of tumor-targeted nanovehicle peptide-conjugated PSPG (PSPGP) is successfully synthesized for co-delivery of paclitaxel (PTX) and TR3 small interfering RNA (siRNA). In vitro and in vivo investigations demonstrate that the redox-responsive PSPGP exhibit enhanced endosomal escape and intracellular degradation, which facilitate PTX and TR3 siRNA release, effectively improving the antitumor efficacy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Peptídeos / Paclitaxel / RNA Interferente Pequeno / Dendrímeros / Membro 1 do Grupo A da Subfamília 4 de Receptores Nucleares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Peptídeos / Paclitaxel / RNA Interferente Pequeno / Dendrímeros / Membro 1 do Grupo A da Subfamília 4 de Receptores Nucleares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article