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Luteolin ameliorates colistin-induced nephrotoxicity in the rat models.
Arslan, Birsen Yigit; Arslan, Ferhat; Erkalp, Kerem; Alagöl, Aysin; Sevdi, Mehmet Salih; Yildiz, Günes; Küçük, Suat Hayri; Altinay, Serdar.
Afiliação
  • Arslan BY; a Department of Anesthesia and Reanimation, Faculty of Medicine , Esenyurt State Hospital , Istanbul , Turkey.
  • Arslan F; b Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine , Istanbul Medeniyet University , Istanbul , Turkey.
  • Erkalp K; c Department of Anesthesia and Reanimation , Bagcilar Education and Training Hospital , Istanbul , Turkey.
  • Alagöl A; c Department of Anesthesia and Reanimation , Bagcilar Education and Training Hospital , Istanbul , Turkey.
  • Sevdi MS; c Department of Anesthesia and Reanimation , Bagcilar Education and Training Hospital , Istanbul , Turkey.
  • Yildiz G; c Department of Anesthesia and Reanimation , Bagcilar Education and Training Hospital , Istanbul , Turkey.
  • Küçük SH; d Department of Biochemistry , Bagcilar Education and Training Hospital , Istanbul , Turkey.
  • Altinay S; e Department of Pathology, Faculty of Medicine , Selçuk University , Konya , Turkey.
Ren Fail ; 38(10): 1735-1740, 2016 Nov.
Article em En | MEDLINE | ID: mdl-27764981
ABSTRACT
INTRODUCTION AND

AIM:

To study the protective, preventive effect of luteolin from colistin-induced nephrotoxicity. MATERIAL AND

METHOD:

Four different treatment options were tested on rats colistin, luteolin, and a combination of colistin and luteolin, intraperitoneally as two doses a day, for seven days. Another group of rats were used as the control and treated with sterile saline. Serum creatinine levels were measured before and after treatment. Histological changes and colistin-induced apoptosis (Insitu BrdU-red DNA Fragmentation Assay Kit) of the renal tissues were examined after the scarification procedure.

RESULTS:

In the Colistin Group, post-treatment creatinine levels were statistically higher than the pretreatment levels (p = .001). In the remaining groups, no significant changes were observed. Cells that undergo apoptosis were counted and it was shown that all groups except the colistin-treated group had a similar number of apoptotic cells, whereas the colistin-treated group had statistically higher number of apoptotic cells compared to other groups (p = .0001). Renal histological damage was also measured and the score of the colistin treated group was higher as compared to other groups.

CONCLUSION:

The results obtained from this study demonstrated us that luteolin was capable of preventing colistin-induced nephrotoxicity and that this effect was significant at histopathological level.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colistina / Luteolina / Nefropatias / Antibacterianos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colistina / Luteolina / Nefropatias / Antibacterianos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article