Febrile infection-related epilepsy syndrome treated with anakinra.
Ann Neurol
; 80(6): 939-945, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27770579
ABSTRACT
Febrile infection-related epilepsy syndrome (FIRES) is a devastating epileptic encephalopathy with limited treatment options and an unclear etiology. Anakinra is a recombinant version of the human interleukin-1 receptor antagonist used to treat autoinflammatory disorders. This is the first report of anakinra for treatment of a child with super-refractory status epilepticus secondary to FIRES. Anakinra was well tolerated and effective. Cerebral spinal fluid analysis revealed elevated levels of proinflammatory cytokines before treatment that normalized on anakinra, suggesting a potential pathogenic role for neuroinflammation in FIRES. Further studies are required to assess anakinra efficacy and dosing, and to further delineate disease etiology. Ann Neurol 2016;80939-945.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estado Epiléptico
/
Convulsões Febris
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Proteína Antagonista do Receptor de Interleucina 1
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Encefalite Infecciosa
Limite:
Child, preschool
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Female
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Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article