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Tyrosinase inhibitory components from Aloe vera and their antiviral activity.
Kim, Jang Hoon; Yoon, Ju-Yeon; Yang, Seo Young; Choi, Seung-Kook; Kwon, Sun Jung; Cho, In Sook; Jeong, Min Hee; Ho Kim, Young; Choi, Gug Seoun.
Afiliação
  • Kim JH; a Department of Horticultural and Crop Environment , National Institute of Horticultural and Herbal Science, RDA , Wanju , Republic of Korea.
  • Yoon JY; a Department of Horticultural and Crop Environment , National Institute of Horticultural and Herbal Science, RDA , Wanju , Republic of Korea.
  • Yang SY; b College of Pharmacy, Chungnam National University , Daejeon , Republic of Korea.
  • Choi SK; a Department of Horticultural and Crop Environment , National Institute of Horticultural and Herbal Science, RDA , Wanju , Republic of Korea.
  • Kwon SJ; a Department of Horticultural and Crop Environment , National Institute of Horticultural and Herbal Science, RDA , Wanju , Republic of Korea.
  • Cho IS; a Department of Horticultural and Crop Environment , National Institute of Horticultural and Herbal Science, RDA , Wanju , Republic of Korea.
  • Jeong MH; b College of Pharmacy, Chungnam National University , Daejeon , Republic of Korea.
  • Ho Kim Y; b College of Pharmacy, Chungnam National University , Daejeon , Republic of Korea.
  • Choi GS; a Department of Horticultural and Crop Environment , National Institute of Horticultural and Herbal Science, RDA , Wanju , Republic of Korea.
J Enzyme Inhib Med Chem ; 32(1): 78-83, 2017 Dec.
Article em En | MEDLINE | ID: mdl-27778516
ABSTRACT
A new compound, 9-dihydroxyl-2'-O-(Z)-cinnamoyl-7-methoxy-aloesin (1), and eight known compounds (2-9) were isolated from Aloe vera. Their structures were elucidated using 1D/2D nuclear magnetic resonance and mass spectra. Compound 9 exhibited reversible competitive inhibitory activity against the enzyme tyrosinase, with an IC50 value of 9.8 ± 0.9 µM. A molecular simulation revealed that compound 9 interacts via hydrogen bonding with residues His244, Thr261, and Val283 of tyrosinase. Additionally, compounds 3 and 7 were shown by half-leaf assays to exhibit inhibitory activity towards Pepper mild mottle virus.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Extratos Vegetais / Monofenol Mono-Oxigenase / Inibidores Enzimáticos / Aloe Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Extratos Vegetais / Monofenol Mono-Oxigenase / Inibidores Enzimáticos / Aloe Idioma: En Ano de publicação: 2017 Tipo de documento: Article