Synthesis, structure-activity relationship and molecular docking of 3-oxoaurones and 3-thioaurones as acetylcholinesterase and butyrylcholinesterase inhibitors.

Mughal, Ehsan Ullah; Sadiq, Amina; Murtaza, Shahzad; Rafique, Hummera; Zafar, Muhammad Naveed; Riaz, Tauqeer; Khan, Bilal Ahmad; Hameed, Abdul; Khan, Khalid Mohammed

Mughal, Ehsan Ullah; Sadiq, Amina; Murtaza, Shahzad; Rafique, Hummera; Zafar, Muhammad Naveed; Riaz, Tauqeer; Khan, Bilal Ahmad; Hameed, Abdul; Khan, Khalid Mohammed.

Afiliação

Mughal EU; Department of Chemistry, University of Gujrat, Gujrat 50700, Pakistan. Electronic address: ehsan.ullah@uog.edu.pk.
Sadiq A; Department of Chemistry, Govt. College Women University, Sialkot 51300, Pakistan.
Murtaza S; Department of Chemistry, University of Gujrat, Gujrat 50700, Pakistan.
Rafique H; Department of Chemistry, University of Gujrat, Gujrat 50700, Pakistan.
Zafar MN; Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Riaz T; Department of Chemistry, University of Gujrat, Gujrat 50700, Pakistan.
Khan BA; Department of Chemistry, University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan.
Hameed A; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Khan KM; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.

Bioorg Med Chem ; 25(1): 100-106, 2017 01 01.

Article em En | MEDLINE | ID: mdl-27780618

Assuntos

Acetilcolinesterase/metabolismo; Benzofuranos/química; Benzofuranos/farmacologia; Butirilcolinesterase/metabolismo; Inibidores da Colinesterase/química; Inibidores da Colinesterase/farmacologia; Acetilcolinesterase/química; Benzofuranos/síntese química; Butirilcolinesterase/química; Inibidores da Colinesterase/síntese química; Humanos; Simulação de Acoplamento Molecular; Termodinâmica

Palavras-chave

3-Thioaurones; AChE/BChE inhibitors; Aurones; Flavonoids; Lawesson's reagent; Molecular docking studies

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Benzofuranos / Butirilcolinesterase / Inibidores da Colinesterase Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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