Synthesis of Chiral Azabicycles from Pyroglutaminols.
Org Lett
; 18(21): 5748-5751, 2016 11 04.
Article
em En
| MEDLINE
| ID: mdl-27786487
ABSTRACT
The stereocontrolled synthesis of a range of substituted bicyclic morpholine and piperazine derivatives is reported from substituted pyroglutaminols via an intramolecular SN2 cyclization as the key step. This enantiospecific approach toward chiral bicyclic morpholines and piperazines offers new opportunities to access these challenging ring systems, which are becoming increasingly common motifs in drug discovery.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article