Epigenetic biomarkers in colorectal cancer: premises and prospects.

ABSTRACT

CONTEXT Colorectal cancer is one of the most common cancers worldwide. Epigenetic alterations play an important role in the pathogenesis of the colorectal cancer. OBJECTIVE: This review has focused on the most recent investigations, which has suggested potential epigenetic biomarkers in colorectal cancer. METHODS: Evidences were achieved by searching online medical databases including Google scholar, Pubmed, Scopus and Science Direct. RESULTS: Extensive studies have indicated that aberrant epigenetic modifications could serve as potential biomarkers for diagnosis, prognosis and prediction of colorectal cancer. CONCLUSION: Advances in aberrant epigenetic modifications can open new avenues for exploration of reliable and robust biomarkers to improve the management of CRC patients.