Active-Site Protonation States in an Acyl-Enzyme Intermediate of a Class A ß-Lactamase with a Monobactam Substrate.

Vandavasi, Venu Gopal; Langan, Patricia S; Weiss, Kevin L; Parks, Jerry M; Cooper, Jonathan B; Ginell, Stephan L; Coates, Leighton

Vandavasi, Venu Gopal; Langan, Patricia S; Weiss, Kevin L; Parks, Jerry M; Cooper, Jonathan B; Ginell, Stephan L; Coates, Leighton.

Afiliação

Vandavasi VG; Biology and Soft Matter Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.
Langan PS; Biology and Soft Matter Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.
Weiss KL; Biology and Soft Matter Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.
Parks JM; Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.
Cooper JB; Birkbeck University of London, London, United Kingdom.
Ginell SL; Structural Biology Center, Argonne National Laboratory, Argonne, Illinois, USA.
Coates L; Biology and Soft Matter Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA coatesl@ornl.gov.

Antimicrob Agents Chemother ; 61(1)2017 01.

Article em En | MEDLINE | ID: mdl-27795378

Assuntos

Antibacterianos/farmacologia; Aztreonam/farmacologia; Monobactamas/farmacologia; beta-Lactamases/metabolismo; Antibacterianos/química; Aztreonam/química; Domínio Catalítico; Cristalografia por Raios X; Testes de Sensibilidade Microbiana; Monobactamas/química; Pseudomonas aeruginosa/efeitos dos fármacos; Pseudomonas aeruginosa/enzimologia; beta-Lactamases/genética

Palavras-chave

X-ray structure; acyl-enzyme complex; aztreonam; neutron structure; ß-lactamase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Aztreonam / Monobactamas / Antibacterianos Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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