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Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction.
Hyde, Alan M; Liu, Zhijian; Kosjek, Birgit; Tan, Lushi; Klapars, Artis; Ashley, Eric R; Zhong, Yong-Li; Alvizo, Oscar; Agard, Nicholas J; Liu, Guiquan; Gu, Xiuyan; Yasuda, Nobuyoshi; Limanto, John; Huffman, Mark A; Tschaen, David M.
Afiliação
  • Hyde AM; Process R&D Department, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Liu Z; Process R&D Department, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Kosjek B; Process R&D Department, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Tan L; Process R&D Department, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Klapars A; Process R&D Department, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Ashley ER; Process R&D Department, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Zhong YL; Process R&D Department, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Alvizo O; Codexis Inc., Redwood City, California 94063, United States.
  • Agard NJ; Codexis Inc., Redwood City, California 94063, United States.
  • Liu G; Shanghai SynTheAll Pharmaceutical Co., Ltd., Jinshan District, Shanghai 201507, China.
  • Gu X; Shanghai SynTheAll Pharmaceutical Co., Ltd., Jinshan District, Shanghai 201507, China.
  • Yasuda N; Process R&D Department, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Limanto J; Process R&D Department, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Huffman MA; Process R&D Department, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
  • Tschaen DM; Process R&D Department, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
Org Lett ; 18(22): 5888-5891, 2016 11 18.
Article em En | MEDLINE | ID: mdl-27802043
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Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Buscar no Google
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article