Your browser doesn't support javascript.
loading
Splenic differentiation and emergence of CCR5+CXCL9+CXCL10+ monocyte-derived dendritic cells in the brain during cerebral malaria.
Hirako, Isabella C; Ataide, Marco A; Faustino, Lucas; Assis, Patricia A; Sorensen, Elizabeth W; Ueta, Hisashi; Araújo, Natalia M; Menezes, Gustavo B; Luster, Andrew D; Gazzinelli, Ricardo T.
Afiliação
  • Hirako IC; Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Av. Augusto de Lima 1715, Barro Preto, Belo Horizonte MG 30190-002, Brazil.
  • Ataide MA; Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, 149 Thirteenth Street, Charlestown, Massachusetts 02129, USA.
  • Faustino L; Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Av. Augusto de Lima 1715, Barro Preto, Belo Horizonte MG 30190-002, Brazil.
  • Assis PA; Departamento de Bioquímica e Imunologia and Centro de Biologia Gastrointestinal, Departamento de Morfologia, Universidade Federal of Minas Gerais, Av. Antonio Carlos 6627, Belo Horizonte MG 31270-901, Brazil.
  • Sorensen EW; Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, 149 Thirteenth Street, Charlestown, Massachusetts 02129, USA.
  • Ueta H; Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Av. Augusto de Lima 1715, Barro Preto, Belo Horizonte MG 30190-002, Brazil.
  • Araújo NM; Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, 149 Thirteenth Street, Charlestown, Massachusetts 02129, USA.
  • Menezes GB; Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, 149 Thirteenth Street, Charlestown, Massachusetts 02129, USA.
  • Luster AD; Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Av. Augusto de Lima 1715, Barro Preto, Belo Horizonte MG 30190-002, Brazil.
  • Gazzinelli RT; Departamento de Bioquímica e Imunologia and Centro de Biologia Gastrointestinal, Departamento de Morfologia, Universidade Federal of Minas Gerais, Av. Antonio Carlos 6627, Belo Horizonte MG 31270-901, Brazil.
Nat Commun ; 7: 13277, 2016 11 03.
Article em En | MEDLINE | ID: mdl-27808089
ABSTRACT
Dendritic cells have an important role in immune surveillance. After being exposed to microbial components, they migrate to secondary lymphoid organs and activate T lymphocytes. Here we show that during mouse malaria, splenic inflammatory monocytes differentiate into monocyte-derived dendritic cells (MO-DCs), which are CD11b+F4/80+CD11c+MHCIIhighDC-SIGNhighLy6c+ and express high levels of CCR5, CXCL9 and CXCL10 (CCR5+CXCL9/10+ MO-DCs). We propose that malaria-induced splenic MO-DCs take a reverse migratory route. After differentiation in the spleen, CCR5+CXCL9/10+ MO-DCs traffic to the brain in a CCR2-independent, CCR5-dependent manner, where they amplify the influx of CD8+ T lymphocytes, leading to a lethal neuropathological syndrome.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Baço / Células Dendríticas / Encéfalo / Malária Cerebral / Linfócitos T CD8-Positivos Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Baço / Células Dendríticas / Encéfalo / Malária Cerebral / Linfócitos T CD8-Positivos Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article