Advances in Aß plaque detection and the value of knowing: overcoming challenges to improving patient outcomes in Alzheimer's disease.
Neurodegener Dis Manag
; 6(6): 491-497, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27813444
Clinical diagnosis of Alzheimer's disease (AD) can be challenging as numerous diseases mimic the characteristics of AD. In this light, recent guidelines developed by different associations and working groups point out the need for biomarkers to support AD diagnosis. This paper discusses 18F-labeled radiotracers (which are indicated for PET imaging of the brain) and ongoing clinical studies that aim to generate new evidence for the usage of amyloid imaging. In addition to their relatively long half-life, these agents are known for their high sensitivity and high negative predictive values for detection of neuritic Aß plaques. Comparisons with other biomarkers are provided and implications of diagnostic disclosures discussed. Finally, recent data from clinical trials underscore the importance of amyloid PET for detecting, quantifying and monitoring Aß plaque deposits.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Placa Amiloide
/
Tomografia por Emissão de Pósitrons
/
Doença de Alzheimer
Tipo de estudo:
Diagnostic_studies
/
Guideline
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article