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Tetanus in Southern Vietnam: Current Situation.
Thuy, Duong Bich; Campbell, James I; Thanh, Tran Tan; Thuy, Cao Thu; Loan, Huynh Thi; Hao, Nguyen Van; Minh, Yen Lam; Tan, Le Van; Boni, Maciej F; Thwaites, C Louise.
Afiliação
  • Thuy DB; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.
  • Campbell JI; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
  • Thanh TT; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
  • Thuy CT; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.
  • Loan HT; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
  • Hao NV; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
  • Minh YL; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
  • Tan LV; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
  • Boni MF; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
  • Thwaites CL; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Am J Trop Med Hyg ; 96(1): 93-96, 2017 Jan 11.
Article em En | MEDLINE | ID: mdl-27821690
In Vietnam, there are no accurate data on tetanus incidence to allow assessment of disease burden or vaccination program efficacy. We analyzed age structure of 786 tetanus cases admitted to a tertiary referral center in Vietnam for three separate years during an 18-year period to examine the impact of tetanus prevention programs, namely the Expanded Program on Immunization (EPI) and the Maternal and Neonatal Tetanus (MNT) initiative. Most cases were born before the initiation of EPI. Median age increased from 33 (interquartile range: 20-52) in 1994, to 46 (32-63) in 2012 (P < 0.001). Birth-year distribution was unchanged, indicating the same birth cohorts presented with tetanus in 1994, 2003, and 2012. Enzyme-linked immunosorbent assay measurements in 90 men and 90 women covered by MNT but not EPI showed 73.3% (95% confidence interval [CI]: 62.9-82.1%) of women had anti-tetanus antibody compared with 24.4% (95% CI: 15.9-34.7%) of men, indicating continued tetanus vulnerability in older men in Vietnam.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tétano / Toxoide Tetânico Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tétano / Toxoide Tetânico Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Ano de publicação: 2017 Tipo de documento: Article