Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor.

Cheng, Xin; Liu, Yong-Qiang; Wang, Gui-Zhen; Yang, Li-Na; Lu, Yong-Zhi; Li, Xin-Chun; Zhou, Bo; Qu, Li-Wei; Wang, Xiao-Lu; Cheng, Yong-Xian; Liu, Jinsong; Tao, Sheng-Ce; Zhou, Guang-Biao

Cheng, Xin; Liu, Yong-Qiang; Wang, Gui-Zhen; Yang, Li-Na; Lu, Yong-Zhi; Li, Xin-Chun; Zhou, Bo; Qu, Li-Wei; Wang, Xiao-Lu; Cheng, Yong-Xian; Liu, Jinsong; Tao, Sheng-Ce; Zhou, Guang-Biao.

Afiliação

Cheng X; Division of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Liu YQ; Division of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Wang GZ; Division of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Yang LN; Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China.
Lu YZ; Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Li XC; Division of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Zhou B; Division of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Qu LW; Division of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Wang XL; Division of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Cheng YX; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Liu J; Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Tao SC; Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China.
Zhou GB; Division of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

Oncotarget ; 8(2): 2681-2693, 2017 Jan 10.

Article em En | MEDLINE | ID: mdl-27835873

Assuntos

Antineoplásicos/farmacologia; Proteínas Oncogênicas/metabolismo; Inibidores de Proteínas Quinases/farmacologia; Proteômica; Proteínas Quinases Associadas a Fase S/antagonistas & inibidores; Fator de Transcrição STAT3/metabolismo; Animais; Antineoplásicos/química; Apoptose/efeitos dos fármacos; Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Modelos Animais de Doenças; Regulação da Expressão Gênica; Humanos; Lactonas/química; Lactonas/farmacologia; Camundongos; Modelos Moleculares; Conformação Molecular; Proteínas Oncogênicas/antagonistas & inibidores; Proteínas Oncogênicas/química; Ligação Proteica; Inibidores de Proteínas Quinases/química; Proteômica/métodos; Proteínas Quinases Associadas a Fase S/química; Proteínas Quinases Associadas a Fase S/genética; Proteínas Quinases Associadas a Fase S/metabolismo; Fator de Transcrição STAT3/antagonistas & inibidores; Fator de Transcrição STAT3/química; Sesquiterpenos/química; Sesquiterpenos/farmacologia; Relação Estrutura-Atividade; Transcrição Gênica; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

6-O-angeloylplenolin; STAT3 inhibitor; Skp2; lung cancer; proteome microarray

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Oncogênicas / Proteômica / Proteínas Quinases Associadas a Fase S / Inibidores de Proteínas Quinases / Fator de Transcrição STAT3 / Antineoplásicos Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google