Microbial genome-wide association studies: lessons from human GWAS.
Nat Rev Genet
; 18(1): 41-50, 2017 01.
Article
em En
| MEDLINE
| ID: mdl-27840430
ABSTRACT
The reduced costs of sequencing have led to whole-genome sequences for a large number of microorganisms, enabling the application of microbial genome-wide association studies (GWAS). Given the successes of human GWAS in understanding disease aetiology and identifying potential drug targets, microbial GWAS are likely to further advance our understanding of infectious diseases. These advances include insights into pressing global health problems, such as antibiotic resistance and disease transmission. In this Review, we outline the methodologies of GWAS, the current state of the field of microbial GWAS, and how lessons from human GWAS can direct the future of the field.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Genoma Humano
/
Doenças Transmissíveis
/
Predisposição Genética para Doença
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Estudo de Associação Genômica Ampla
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Genoma Microbiano
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article