Variation in alpha-1-antitrypsin phenotypes associated with penicillamine therapy.
Clin Chim Acta
; 179(1): 109-15, 1989 Jan 13.
Article
em En
| MEDLINE
| ID: mdl-2784082
ABSTRACT
During a detailed study of alpha-1-antitrypsin (AAT) by isoelectric focusing, of 130 individuals of the PiZ phenotype and their families, an unusual alpha-1-antitrypsin protein pattern was identified which related directly to the effect of penicillamine therapy. The effect, believed to be mediated by reaction with the free cysteine of the alpha-1-antitrypsin molecule, was demonstrable by in vitro experiments. It was not apparently associated with loss of the anti-proteinase properties of alpha-1-antitrypsin and was not specific to the Z gene products. It is however, a source of possible confusion in the accurate assessment of Pi phenotypes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Penicilamina
/
Fenótipo
/
Alfa 1-Antitripsina
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article