Impaired thromboxane receptor dimerization reduces signaling efficiency: A potential mechanism for reduced platelet function in vivo.

Capra, Valérie; Mauri, Mario; Guzzi, Francesca; Busnelli, Marta; Accomazzo, Maria Rosa; Gaussem, Pascale; Nisar, Shaista P; Mundell, Stuart J; Parenti, Marco; Rovati, G Enrico

Capra, Valérie; Mauri, Mario; Guzzi, Francesca; Busnelli, Marta; Accomazzo, Maria Rosa; Gaussem, Pascale; Nisar, Shaista P; Mundell, Stuart J; Parenti, Marco; Rovati, G Enrico.

Afiliação

Capra V; Department of Pharmacological and Biomolecular Sciences, University of Milan, Milano, Italy; Department of Health Science, University of Milan, Milano, Italy. Electronic address: Valerie.Capra@unimi.it.
Mauri M; Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy. Electronic address: mario.mauri@unimib.it.
Guzzi F; Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy. Electronic address: francesca.guzzi@unimib.it.
Busnelli M; CNR, Institute of Neuroscience, University of Milan, Milan, Italy; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy. Electronic address: m.busnelli@in.cnr.com.
Accomazzo MR; Department of Pharmacological and Biomolecular Sciences, University of Milan, Milano, Italy. Electronic address: Maria.Accomazzo@unimi.it.
Gaussem P; Inserm UMR-S1140, Faculte' de Pharmacie, Université Paris Descartes, Sorbonne Paris Cité, Paris and AP-HP, Hopital Européen Georges Pompidou, Service d'Hématologie Biologique, Paris, France. Electronic address: pascale.gaussem@univ-paris5.fr.
Nisar SP; School of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, UK. Electronic address: shaista.nisar@bristol.ac.uk.
Mundell SJ; School of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, UK. Electronic address: s.j.mundell@bristol.ac.uk.
Parenti M; Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy. Electronic address: marco.parenti@unimib.it.
Rovati GE; Department of Pharmacological and Biomolecular Sciences, University of Milan, Milano, Italy. Electronic address: Genrico.Rovati@unimi.it.

Biochem Pharmacol ; 124: 43-56, 2017 Jan 15.

Article em En | MEDLINE | ID: mdl-27845050

Assuntos

Plaquetas/fisiologia; Receptores de Tromboxanos/metabolismo; Transdução de Sinais; Dimerização; Relação Dose-Resposta a Droga; Células HEK293; Humanos; Ligantes; Mutação; Receptores de Tromboxanos/agonistas; Receptores de Tromboxanos/antagonistas & inibidores; Receptores de Tromboxanos/genética

Palavras-chave

(Z)-7-[(1R,2R,3R,4S)-3-[[2-(phenylcarbamoyl)hydrazinyl]methyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid; (Z)-7-[(1S,2S,3R,4R)-3-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid; (Z)-7-[(1S,2S,3S,4R)-3-[(E,3R)-3-hydroxy-4-(4-iodophenoxy)but-1-enyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid; (Z)-7-[(1S,3R,4R,5S)-3-[(E,3R)-3-hydroxyoct-1-enyl]-6,6-dimethyl-4-bicyclo[3.1.1]heptanyl]hept-5-enoic acid; 3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid; Eicosanoids; G protein coupled receptors; I-BOP (PubChem CID: 51015454); Pinane Thromboxane A2 (PTA2) (PubChem CID: 25834471); Platelets; Ramatroban (PubChem CID: 123879); Receptor dimer; SQ29,548 (PubChem CID: 6437074); Signal transduction; Thromboxane A(2); U46619 (PubChem CID: 5311493)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plaquetas / Transdução de Sinais / Receptores de Tromboxanos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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