TUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin.

Xiaobo, Cao; Majidi, Mourad; Feng, Meng; Shao, Ruping; Wang, Jing; Zhao, Yang; Baladandayuthapani, Veerabhadran; Song, Juhee; Fang, Bingliang; Ji, Lin; Mehran, Reza; Roth, Jack A

Xiaobo, Cao; Majidi, Mourad; Feng, Meng; Shao, Ruping; Wang, Jing; Zhao, Yang; Baladandayuthapani, Veerabhadran; Song, Juhee; Fang, Bingliang; Ji, Lin; Mehran, Reza; Roth, Jack A.

Afiliação

Xiaobo C; Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, University of Texas (UT) MD Anderson Cancer Center, Houston, TX, USA.
Majidi M; Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, University of Texas (UT) MD Anderson Cancer Center, Houston, TX, USA.
Feng M; Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, University of Texas (UT) MD Anderson Cancer Center, Houston, TX, USA.
Shao R; Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, University of Texas (UT) MD Anderson Cancer Center, Houston, TX, USA.
Wang J; Department of Bioinfomatics and Computational Biology, UT MD Anderson Cancer Center, Houston, TX, USA.
Zhao Y; Department of Bioinfomatics and Computational Biology, UT MD Anderson Cancer Center, Houston, TX, USA.
Baladandayuthapani V; Department of Biostatistics, UT MD Anderson Cancer Center, Houston, TX, USA.
Song J; Department of Biostatistics, UT MD Anderson Cancer Center, Houston, TX, USA.
Fang B; Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, University of Texas (UT) MD Anderson Cancer Center, Houston, TX, USA.
Ji L; Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, University of Texas (UT) MD Anderson Cancer Center, Houston, TX, USA.
Mehran R; Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, University of Texas (UT) MD Anderson Cancer Center, Houston, TX, USA.
Roth JA; Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, University of Texas (UT) MD Anderson Cancer Center, Houston, TX, USA.

Sci Rep ; 6: 35741, 2016 11 15.

Article em En | MEDLINE | ID: mdl-27845352

Assuntos

Auranofina/farmacologia; Carcinoma Pulmonar de Células não Pequenas/metabolismo; Receptores ErbB/biossíntese; Cloridrato de Erlotinib/farmacologia; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Neoplasias Pulmonares/metabolismo; Proteínas Supressoras de Tumor/biossíntese; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Carcinoma Pulmonar de Células não Pequenas/genética; Carcinoma Pulmonar de Células não Pequenas/patologia; Linhagem Celular; Receptores ErbB/genética; Humanos; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Proteínas Supressoras de Tumor/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Auranofina / Carcinoma Pulmonar de Células não Pequenas / Proteínas Supressoras de Tumor / Receptores ErbB / Cloridrato de Erlotinib / Neoplasias Pulmonares Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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